منابع مشابه
Targeted therapy in pediatric low-grade glioma.
Collectively, pediatric low-grade gliomas account for most brain tumors reported in children. Surgery is typically curable for operable lesions. However, more effective therapies are required for inaccessible tumors, both to overcome refractory disease and to minimize the toxicity associated with conventional adjuvant chemotherapy and radiotherapy regimens. Recent years have witnessed rapid imp...
متن کاملManagement of Low-Grade Glioma
The optimal management of patients with low-grade glioma (LGG) is controversial. The controversy largely stems from the lack of well-designed clinical trials with adequate follow-up to account for the relatively long progression-free survival and overall survival of patients with LGG. Nonetheless, the literature increasingly suggests that expectant management is no longer optimal. Rather, there...
متن کاملThe dilemma of low grade glioma.
Correspondence to: Professor Ian R Whittle, Department of Clinical Neuroscience, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; [email protected] _________________________ T he management of low grade glioma is one of the most controversial areas in clinical neurooncology. There are numerous reviews and editorials outlining the difficulties in management of these lesions. Ind...
متن کاملWhite matter compromise predicts poor intellectual outcome in survivors of pediatric low-grade glioma.
BACKGROUND While the impact of cranial radiation on white matter following treatment for pediatric brain tumor has been the focus of many recent studies, the effect of treatment in the absence of radiation has received little attention. The relations between white matter and cognitive outcome have not been explored in patients who have undergone radiation-free treatment. As most patients treate...
متن کاملIncidence of kiaa1549-braf fusion gene in Egyptian pediatric low grade glioma
BACKGROUND Low grade gliomas are the most common brain tumor in children. Tandem duplication involving the KIAA1549 and the BRAF kinase genes results in a gene fusion that has been recently characterized in a subset of low grade glioma While there is no clear evidence that the KIAA1549-BRAF gene fusion has an effect on prognosis, it is an attractive target for therapy development and as a diagn...
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ژورنال
عنوان ژورنال: Journal of Radiation Oncology
سال: 2012
ISSN: 1948-7894,1948-7908
DOI: 10.1007/s13566-012-0078-z